Interactive Toxicity Nomograms
Ars Informatica would like to present interactive versions of the Rumack-Matthew and Done nomograms, used to estimate the toxicity associated with an acute acetaminophen or salicylate overdose.
Just enter the time since ingestion, and serum plasma level in either SI or US units, and our software routine automatically plots the result on the nomogram.
Provisos do, of course, apply. These nomograms are only for the acute overdose; chronic ingestion can result in severe toxicity or death with much lower serum levels.
Even in the acute overdose, actual clinical toxicity can vary from that suggested by the plotted values. Individual clinical responses can vary greatly, and a lethal overdose in one person might be mild or moderate in another. Conversely, a patient may be sicker than the numbers suggest. The Done nomogram in particular is less accurate than desired.
Let your actions be guided, not by the value, but by the patient.
Please choose one of the following:
Rumack-Matthew Nomogram for Acetaminophen Toxicity
Done Nomogram for Salicylate Toxicity
Toxicity Nomographs: GIF versions of the Rumack-Matthew and Done nomograms for Acute Acetaminophen and Salicylate Toxicity